Shrimp Di Santo is a delightful Sicilian-inspired dish that exudes the flavors of the Mediterranean. This recipe, passed down from Mabel and Santo Formica, promises to tantalize your taste buds with its savory blend of fresh shrimp, aromatic garlic, and fragrant olive oil. Whether served over pasta as a main course or presented as an elegant appetizer, Shrimp Di Santo is sure to impress even the most discerning of palates.
With a quick and easy preparation time of just 20 minutes and a total cooking time of 40 minutes, this dish is perfect for those seeking a delicious meal without the hassle of lengthy cooking processes. Clocking in at under an hour, it’s ideal for busy weeknights or leisurely weekend gatherings where time is of the essence.

To create this culinary masterpiece, begin by preparing your shrimp. Peel and devein the shrimp, if desired, and place them in a large bowl. This step sets the stage for the infusion of flavors that will elevate your dish to new heights.
Next, sprinkle the shrimp with a generous amount of garlic powder and seasoning salt, ensuring that each succulent morsel is thoroughly coated with these aromatic seasonings. The garlic adds depth and complexity to the dish, while the seasoning salt enhances the natural flavors of the shrimp, resulting in a harmonious marriage of taste sensations.
Once the shrimp are seasoned to perfection, drizzle them with olive oil, tossing well to ensure even distribution of the flavorful oil. Olive oil not only adds richness and moisture to the dish but also imparts a distinctive Mediterranean flair that is characteristic of Sicilian cuisine.
To add a satisfying crunch to the dish, sprinkle the shrimp with a breadcrumb mixture, tossing gently to coat each shrimp with a delectable layer of crunchy goodness. The breadcrumbs create a crispy exterior that contrasts beautifully with the tender flesh of the shrimp, adding both texture and visual appeal to the dish.
Now it’s time to arrange the shrimp in a single layer on a generously greased 15″ x 9″ jellyroll pan, ensuring that they are evenly spaced to allow for even cooking. This step is crucial for achieving perfectly cooked shrimp that are tender on the inside and golden brown and crispy on the outside.
Pop the pan into a preheated 400ºF oven and let the magic happen. Bake the shrimp for 20 minutes, stirring twice during the cooking process to ensure that they cook evenly and develop a gorgeous golden hue.
Once cooked to perfection, remove the pan from the oven and marvel at the irresistible aroma that fills your kitchen. The shrimp should be tender and juicy, with a crispy breadcrumb coating that beckons you to dig in.
Serve the Shrimp Di Santo warm, either as a standalone appetizer or atop a bed of al dente pasta for a more substantial meal. Garnish with fresh herbs or a squeeze of lemon juice for a burst of brightness that enhances the flavors of the dish.
As you take your first bite, savor the exquisite flavors of the Mediterranean as they dance across your palate. Each mouthful is a symphony of taste sensations, with the sweetness of the shrimp perfectly complemented by the savory garlic, fragrant olive oil, and crispy breadcrumb coating.
With a perfect five-star rating and rave reviews from satisfied diners, Shrimp Di Santo is a guaranteed crowd-pleaser that will have your guests coming back for seconds and asking for the recipe. And with just 209.2 calories per serving and a wealth of essential nutrients, including protein, fiber, and healthy fats, you can indulge in this culinary delight guilt-free.
So why wait? Gather your ingredients and prepare to embark on a culinary journey to Sicily with Shrimp Di Santo. With its irresistible flavors and effortless preparation, it’s a recipe that’s sure to become a staple in your repertoire for years to come. Buon appetito!